AKAP1 Deficiency Attenuates Diet‐Induced Obesity and Insulin Resistance by Promoting Fatty Acid Oxidation and Thermogenesis in Brown Adipocytes

AKAP1 Deficiency Attenuates Diet‐Induced Obesity and Insulin Resistance by Promoting Fatty Acid Oxidation and Thermogenesis in Brown Adipocytes

Abstract Altering the balance between energy intake and expenditure is a major strategy for treating obesity. Nonetheless, despite the progression in antiobesity drugs on appetite suppression, therapies aimed at increasing energy expenditure are limited. Here, knockout ofAKAP1, a signaling hub on ou...

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Bibliographic Details
Main Authors: Lele Ji, Ya Zhao, Linjie He, Jing Zhao, Tian Gao, Fengzhou Liu, Bingchao Qi, Fei Kang, Gang Wang, Yilin Zhao, Haitao Guo, Yuanfang He, Fei Li, Qichao Huang, Jinliang Xing
Format: Article
Language:English
Published: Wiley 2021-03-01
Series:Advanced Science
Subjects:
AKAP1
diet‐induced obesity
fatty acid β‐oxidation
insulin resistance
mitochondrial thermogenesis
Online Access:https://doi.org/10.1002/advs.202002794

Internet

https://doi.org/10.1002/advs.202002794

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