Type I Interferon Signaling Is Required for CpG-Oligodesoxynucleotide-Induced Control of Leishmania major, but Not for Spontaneous Cure of Subcutaneous Primary or Secondary L. major Infection

Type I Interferon Signaling Is Required for CpG-Oligodesoxynucleotide-Induced Control of Leishmania major, but Not for Spontaneous Cure of Subcutaneous Primary or Secondary L. major Infection

We previously showed that in mice infected with Leishmania major type I interferons (IFNs) initiate the innate immune response to the parasite at day 1 and 2 of infection. Here, we investigated which type I IFN subtypes are expressed during the first 8 weeks of L. major infection and whether type I...

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Bibliographic Details
Main Authors: Ulrike Schleicher, Jan Liese, Nicole Justies, Thomas Mischke, Simone Haeberlein, Heidi Sebald, Ulrich Kalinke, Siegfried Weiss, Christian Bogdan
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Immunology
Subjects:
Leishmania major
type I interferon
interferon-alpha/beta
innate immunity
cutaneous leishmaniasis
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00079/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00079/full

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