Decreased iPLA2γ expression induces lipid peroxidation and cell death and sensitizes cells to oxidant-induced apoptosis*

Decreased iPLA2γ expression induces lipid peroxidation and cell death and sensitizes cells to oxidant-induced apoptosis*

Our previous studies showed that renal proximal tubular cells (RPTC) express Ca2+-independent phospholipase A2γ (iPLA2γ) in endoplasmic reticulum (ER) and mitochondria and that iPLA2γ prevents and/or repairs lipid peroxidation induced by oxidative stress. Our present studies determined the importanc...

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Bibliographic Details
Main Authors: Gilbert R. Kinsey, Jason L. Blum, Marisa D. Covington, Brian S. Cummings, Jane McHowat, Rick G. Schnellmann
Format: Article
Language:English
Published: Elsevier 2008-07-01
Series:Journal of Lipid Research
Subjects:
Ca2+-independent phospholipase A2
renal proximal tubular cells
mitochondria
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520347192

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http://www.sciencedirect.com/science/article/pii/S0022227520347192

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