Exosome secreted from adipose-derived stem cells attenuates diabetic nephropathy by promoting autophagy flux and inhibiting apoptosis in podocyte

Exosome secreted from adipose-derived stem cells attenuates diabetic nephropathy by promoting autophagy flux and inhibiting apoptosis in podocyte

Abstract Background It is confirmed that adipose-derived stem cells (ADSCs) transplantation effectively relieves kidney fibrosis and type 2 diabetes disease in mice. Currently, exosome from urine-derived stem cells (USCs) can protect type 1 diabetes-mediated kidney injury and attenuate podocyte dama...

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Bibliographic Details
Main Authors: Juan Jin, Yifen Shi, Jianguang Gong, Li Zhao, Yiwen Li, Qiang He, He Huang
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Stem Cell Research & Therapy
Subjects:
Adipose-derived stem cells
Exosome
Podocyte damage
Cell autophagy
miR-486
Smad1/mTOR signaling
Online Access:http://link.springer.com/article/10.1186/s13287-019-1177-1

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http://link.springer.com/article/10.1186/s13287-019-1177-1

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