Packpred: Predicting the Functional Effect of Missense Mutations

Packpred: Predicting the Functional Effect of Missense Mutations

Predicting the functional consequences of single point mutations has relevance to protein function annotation and to clinical analysis/diagnosis. We developed and tested Packpred that makes use of a multi-body clique statistical potential in combination with a depth-dependent amino acid substitution...

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Bibliographic Details
Main Authors: Kuan Pern Tan, Tejashree Rajaram Kanitkar, Chee Keong Kwoh, Mallur Srivatsan Madhusudhan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Molecular Biosciences
Subjects:
missense mutation effect prediction
amino acid depth
local environment/clique
statistical potential
meta predictor
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.646288/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2021.646288/full

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