Structure, Activity and Function of the Suv39h1 and Suv39h2 Protein Lysine Methyltransferases

SUV39H1 and SUV39H2 were the first protein lysine methyltransferases that were identified more than 20 years ago. Both enzymes introduce di- and trimethylation at histone H3 lysine 9 (H3K9) and have important roles in the maintenance of heterochromatin and gene repression. They consist of a catalyti...

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Bibliographic Details
Main Authors: Sara Weirich, Mina S. Khella, Albert Jeltsch
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Life
Subjects:
Online Access:https://www.mdpi.com/2075-1729/11/7/703