Injectable exosome-functionalized extracellular matrix hydrogel for metabolism balance and pyroptosis regulation in intervertebral disc degeneration

Injectable exosome-functionalized extracellular matrix hydrogel for metabolism balance and pyroptosis regulation in intervertebral disc degeneration

Abstract Exosome therapy is a promising therapeutic approach for intervertebral disc degeneration (IVDD) and achieves its therapeutic effects by regulating metabolic disorders, the microenvironment and cell homeostasis with the sustained release of microRNAs, proteins, and transcription factors. How...

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Bibliographic Details
Main Authors: Hongyuan Xing, Zengjie Zhang, Qijiang Mao, Chenggui Wang, Youlong Zhou, Xiaopeng Zhou, Liwei Ying, Haibin Xu, Shaojun Hu, Ning Zhang
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Journal of Nanobiotechnology
Subjects:
Intervertebral disc degeneration
Exosome
Extracellular matrix
Pyroptosis
Tissue engineering
Online Access:https://doi.org/10.1186/s12951-021-00991-5

Internet

https://doi.org/10.1186/s12951-021-00991-5

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