A P2rx7 Passenger Mutation Affects the Vitality and Function of T cells in Congenic Mice

A P2rx7 Passenger Mutation Affects the Vitality and Function of T cells in Congenic Mice

Summary: Among laboratory mouse strains many genes are differentially expressed in the same cell population. As consequence, gene targeting in 129-derived embryonic stem cells (ESCs) and backcrossing the modified mice onto the C57BL/6 background can introduce passenger mutations in the close proximi...

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Bibliographic Details
Main Authors: Marco Er-Lukowiak, Yinghui Duan, Francois Rassendren, Lauriane Ulmann, Annette Nicke, Friederike Ufer, Manuel A. Friese, Friedrich Koch-Nolte, Tim Magnus, Björn Rissiek
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:iScience
Subjects:
Genetics
Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220310671

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http://www.sciencedirect.com/science/article/pii/S2589004220310671

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