Intrathecal infusion of hydrogen-rich normal saline attenuates neuropathic pain via inhibition of activation of spinal astrocytes and microglia in rats.

BACKGROUND: Reactive oxygen and nitrogen species are key molecules that mediate neuropathic pain. Although hydrogen is an established antioxidant, its effect on chronic pain has not been characterized. This study was to investigate the efficacy and mechanisms of hydrogen-rich normal saline induced a...

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Bibliographic Details
Main Authors: Yanhu Ge, Feixiang Wu, Xuejun Sun, Zhenghua Xiang, Liqun Yang, Shengdong Huang, Zhijie Lu, Yuming Sun, Wei-Feng Yu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4032255?pdf=render