The GPR18 Agonist PSB-KD-107 Exerts Endothelium-Dependent Vasorelaxant Effects

GPR18 is an orphan GPCR that is activated by the cannabinoid tetrahydrocannabinol (THC). Emerging evidence indicates its involvement in the control of cardiovascular functions, including heart rate, contractility, vascular tone, as well as blood pressure. Therefore, we investigated the effects of se...

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Bibliographic Details
Main Authors: Magdalena Kotańska, Monika Kubacka, Marek Bednarski, Noemi Nicosia, Małgorzata Szafarz, Wojciech Jawień, Christa E. Müller, Katarzyna Kieć-Kononowicz
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Pharmaceuticals
Subjects:
Online Access:https://www.mdpi.com/1424-8247/14/8/799