Pharmacological blockade of the fatty acid amide hydrolase (FAAH) alters neural proliferation, apoptosis and gliosis in the rat hippocampus, hypothalamus and striatum in a negative energy context

Pharmacological blockade of the fatty acid amide hydrolase (FAAH) alters neural proliferation, apoptosis and gliosis in the rat hippocampus, hypothalamus and striatum in a negative energy context

Endocannabinoids participate in the control of neurogenesis, neural cell death and gliosis. The pharmacological effect of the fatty acid amide hydrolase (FAAH) inhibitor URB597, which limits the endocannabinoid degradation, was investigated in the present study. Cell proliferation (phospho-H3+ or Br...

Full description

Bibliographic Details
Main Authors: Patricia eRivera, Laura eBindila, Antoni ePastor, Margarita ePérez-Martín, Francisco Javier ePavon, Antonia eSerrano, Rafael eDe La Torre, Beat eLutz, Fernando eRodríguez de Fonseca, Juan eSuarez
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-03-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Cannabinoids
Energy Metabolism
Gliosis
Neurogenesis
FAAH
URB597
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00098/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00098/full

Similar Items