Obesity impacts brain metabolism and structure independently of amyloid and tau pathology in healthy elderly

Obesity impacts brain metabolism and structure independently of amyloid and tau pathology in healthy elderly

Abstract Aims/hypothesis Midlife obesity is a risk factor for dementia. We investigated the impact of obesity on brain structure, metabolism, and cerebrospinal fluid (CSF) core Alzheimer's disease (AD) biomarkers in healthy elderly. Methods We selected controls from ADNI2 with CSF AD biomarkers...

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Bibliographic Details
Main Authors: Jordi Pegueroles, Adriana Pané, Eduard Vilaplana, Víctor Montal, Alexandre Bejanin, Laura Videla, María Carmona‐Iragui, Isabel Barroeta, Ainitze Ibarzabal, Anna Casajoana, Daniel Alcolea, Silvia Valldeneu, Miren Altuna, Ana deHollanda, Josep Vidal, Emilio Ortega, Ricardo Osorio, Antonio Convit, Rafael Blesa, Alberto Lleó, Juan Fortea, Amanda Jiménez, Alzheimer's Disease Neuroimaging Initiative
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
Subjects:
body mass index
cerebrospinal fluid Alzheimer's disease biomarkers
fluorodeoxyglucose PET
magnetic resonance imaging
obesity
pre‐clinical Alzheimer's disease
Online Access:https://doi.org/10.1002/dad2.12052

Internet

https://doi.org/10.1002/dad2.12052

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