A miR-200b/200c/429-binding site polymorphism in the 3' untranslated region of the AP-2α gene is associated with cisplatin resistance.

A miR-200b/200c/429-binding site polymorphism in the 3' untranslated region of the AP-2α gene is associated with cisplatin resistance.

The transcription factor AP-2α functions as a tumor suppressor by regulating various genes that are involved in cell proliferation and apoptosis. Chemotherapeutic drugs including cisplatin induce post-transcriptionally endogenous AP-2α, which contributes to chemosensitivity by enhancing therapy-indu...

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Bibliographic Details
Main Authors: Yuan Wu, Yuzhong Xiao, Xiaofeng Ding, Yiming Zhuo, Peng Ren, Chang Zhou, Jianlin Zhou
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22194984/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22194984/?tool=EBI

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