WWOX Phosphorylation, Signaling, and Role in Neurodegeneration

WWOX Phosphorylation, Signaling, and Role in Neurodegeneration

Homozygous null mutation of tumor suppressor WWOX/Wwox gene leads to severe neural diseases, metabolic disorders and early death in the newborns of humans, mice and rats. WWOX is frequently downregulated in the hippocampi of patients with Alzheimer’s disease (AD). In vitro analysis revealed that kno...

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Bibliographic Details
Main Authors: Chan-Chuan Liu, Pei-Chuan Ho, I.-Ting Lee, Yu-An Chen, Chun-Hsien Chu, Chih-Chuan Teng, Sheng-Nan Wu, Chun-I. Sze, Ming-Fu Chiang, Nan-Shan Chang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Neuroscience
Subjects:
WWOX
TRAPPC6AΔ
TIAF1
17β-estradiol
sex steroid hormone receptor
neurodegeneration
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2018.00563/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2018.00563/full

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