A comparative analysis of unintegrated HIV-1 DNA measurement as a potential biomarker of the cellular reservoir in the blood of patients controlling and non-controlling viral replication

A comparative analysis of unintegrated HIV-1 DNA measurement as a potential biomarker of the cellular reservoir in the blood of patients controlling and non-controlling viral replication

Abstract Background The persistence of HIV-1 in reservoir cells is one of the major obstacles to eradicating the virus in infected individuals receiving combination antiretroviral therapy (ART). HIV-1 persists in infected cells as a stable integrated genome and more labile unintegrated DNA (uDNA), w...

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Bibliographic Details
Main Authors: Chiara Orlandi, Benedetta Canovari, Federica Bozzano, Francesco Marras, Zeno Pasquini, Francesco Barchiesi, Andrea De Maria, Mauro Magnani, Anna Casabianca
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Journal of Translational Medicine
Subjects:
HIV-1
Total HIV DNA
Unintegrated HIV DNA
2-LTR circles
Reservoir
qPCR
Online Access:http://link.springer.com/article/10.1186/s12967-020-02368-y

Internet

http://link.springer.com/article/10.1186/s12967-020-02368-y

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