Remote Ischemic Pre-Conditioning Attenuates Adverse Cardiac Remodeling and Mortality Following Doxorubicin Administration in Mice

Remote Ischemic Pre-Conditioning Attenuates Adverse Cardiac Remodeling and Mortality Following Doxorubicin Administration in Mice

Objectives: Because of its multifaceted cardioprotective effects, remote ischemic pre-conditioning (RIPC) was examined as a strategy to attenuate doxorubicin (DOX) cardiotoxicity. Background: The use of DOX is limited by dose-dependent cardiotoxicity and heart failure. Oxidative stress, mitochondria...

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Bibliographic Details
Main Authors: Zachary M. Gertz, MD, Chad Cain, BS, Donatas Kraskauskas, DVM, Teja Devarakonda, BS, Adolfo G. Mauro, PhD, Jeremy Thompson, BS, Arun Samidurai, PhD, Qun Chen, PhD, Sarah W. Gordon, DO, Edward J. Lesnefsky, MD, Anindita Das, PhD, Fadi N. Salloum, PhD
Format: Article
Language:English
Published: Elsevier 2019-12-01
Series:JACC. CardioOncology
Subjects:
apoptosis
cardiac fibrosis
doxorubicin
echocardiography
remote ischemic pre-conditioning
Online Access:http://www.sciencedirect.com/science/article/pii/S2666087319300894

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http://www.sciencedirect.com/science/article/pii/S2666087319300894

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