DNA sequence profiles of the colorectal cancer critical gene set KRAS-BRAF-PIK3CA-PTEN-TP53 related to age at disease onset.

DNA sequence profiles of the colorectal cancer critical gene set KRAS-BRAF-PIK3CA-PTEN-TP53 related to age at disease onset.

The incidence of colorectal cancer (CRC) increases with age and early onset indicates an increased likelihood for genetic predisposition for this disease. The somatic genetics of tumor development in relation to patient age remains mostly unknown. We have examined the mutation status of five known c...

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Bibliographic Details
Main Authors: Marianne Berg, Stine A Danielsen, Terje Ahlquist, Marianne A Merok, Trude H Ågesen, Morten H Vatn, Tom Mala, Ole H Sjo, Arne Bakka, Ingvild Moberg, Torunn Fetveit, Øystein Mathisen, Anders Husby, Oddvar Sandvik, Arild Nesbakken, Espen Thiis-Evensen, Ragnhild A Lothe
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-11-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2980471?pdf=render

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http://europepmc.org/articles/PMC2980471?pdf=render

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