Norovirus evolution in immunodeficient mice reveals potentiated pathogenicity via a single nucleotide change in the viral capsid.

Norovirus evolution in immunodeficient mice reveals potentiated pathogenicity via a single nucleotide change in the viral capsid.

Interferons (IFNs) are key controllers of viral replication, with intact IFN responses suppressing virus growth and spread. Using the murine norovirus (MNoV) system, we show that IFNs exert selective pressure to limit the pathogenic evolutionary potential of this enteric virus. In animals lacking ty...

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Bibliographic Details
Main Authors: Forrest C Walker, Ebrahim Hassan, Stefan T Peterson, Rachel Rodgers, Lawrence A Schriefer, Cassandra E Thompson, Yuhao Li, Gowri Kalugotla, Carla Blum-Johnston, Dylan Lawrence, Broc T McCune, Vincent R Graziano, Larissa Lushniak, Sanghyun Lee, Alexa N Roth, Stephanie M Karst, Timothy J Nice, Jonathan J Miner, Craig B Wilen, Megan T Baldridge
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-03-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1009402

Internet

https://doi.org/10.1371/journal.ppat.1009402

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