Pharmacological Inhibition of ATR Can Block Autophagy through an ATR-Independent Mechanism

Pharmacological Inhibition of ATR Can Block Autophagy through an ATR-Independent Mechanism

Summary: Inhibition of the ATR kinase has emerged as a therapeutically attractive means to target cancer since the development of potent inhibitors, which are now in clinical testing. We investigated a potential link between ATR inhibition and the autophagy process in esophageal cancer cells using f...

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Bibliographic Details
Main Authors: Elizabeth Bowler, Anna Skwarska, Joseph D. Wilson, Shaliny Ramachandran, Hannah Bolland, Alistair Easton, Christian Ostheimer, Ming-Shih Hwang, Katarzyna B. Leszczynska, Stuart J. Conway, Ester M. Hammond
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:iScience
Subjects:
Biological Sciences
Biochemistry
Biochemical Mechanism
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220308609

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http://www.sciencedirect.com/science/article/pii/S2589004220308609

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