Mutations Located outside the Integrase Gene Can Confer Resistance to HIV-1 Integrase Strand Transfer Inhibitors

Mutations Located outside the Integrase Gene Can Confer Resistance to HIV-1 Integrase Strand Transfer Inhibitors

Resistance to the integrase strand transfer inhibitors raltegravir and elvitegravir is often due to well-identified mutations in the integrase gene. However, the situation is less clear for patients who fail dolutegravir treatment. Furthermore, most in vitro experiments to select resistance to dolut...

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Bibliographic Details
Main Authors: Isabelle Malet, Frédééric Subra, Charlotte Charpentier, Gilles Collin, Diane Descamps, Vincent Calvez, Anne-Geneviééève Marcelin, Olivier Delelis, Dimitrios Paraskevis
Format: Article
Language:English
Published: American Society for Microbiology 2017-09-01
Series:mBio
Online Access:http://mbio.asm.org/cgi/content/full/8/5/e00922-17

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http://mbio.asm.org/cgi/content/full/8/5/e00922-17

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