Vascular dimorphism ensured by regulated proteoglycan dynamics favors rapid umbilical artery closure at birth

Vascular dimorphism ensured by regulated proteoglycan dynamics favors rapid umbilical artery closure at birth

The umbilical artery lumen closes rapidly at birth, preventing neonatal blood loss, whereas the umbilical vein remains patent longer. Here, analysis of umbilical cords from humans and other mammals identified differential arterial-venous proteoglycan dynamics as a determinant of these contrasting va...

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Bibliographic Details
Main Authors: Sumeda Nandadasa, Jason M Szafron, Vai Pathak, Sae-Il Murtada, Caroline M Kraft, Anna O'Donnell, Christian Norvik, Clare Hughes, Bruce Caterson, Miriam S Domowicz, Nancy B Schwartz, Karin Tran-Lundmark, Martina Veigl, David Sedwick, Elliot H Philipson, Jay D Humphrey, Suneel S Apte
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-09-01
Series:eLife
Subjects:
umbilical cord
proteoglycans
extracellular matrix
vascular smooth muscle
birth
vascular engineering
Online Access:https://elifesciences.org/articles/60683

Internet

https://elifesciences.org/articles/60683

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