Analysis of striatal transcriptome in mice overexpressing human wild-type alpha-synuclein supports synaptic dysfunction and suggests mechanisms of neuroprotection for striatal neurons

Analysis of striatal transcriptome in mice overexpressing human wild-type alpha-synuclein supports synaptic dysfunction and suggests mechanisms of neuroprotection for striatal neurons

<p>Abstract</p> <p>Background</p> <p>Alpha synuclein (SNCA) has been linked to neurodegenerative diseases (synucleinopathies) that include Parkinson's disease (PD). Although the primary neurodegeneration in PD involves nigrostriatal dopaminergic neurons, more exten...

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Bibliographic Details
Main Authors: Cabeza-Arvelaiz Yofre, Fleming Sheila M, Richter Franziska, Masliah Eliezer, Chesselet Marie-Francoise, Schiestl Robert H
Format: Article
Language:English
Published: BMC 2011-12-01
Series:Molecular Neurodegeneration
Subjects:
α-synuclein
apoptosis
neuroprotection
Parkinson's disease
Alzheimer's disease
synaptic plasticity
vesicle release
diabetes
Online Access:http://www.molecularneurodegeneration.com/content/6/1/83

Internet

http://www.molecularneurodegeneration.com/content/6/1/83

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