Current view on the functional regulation of the neuronal K+-Cl- cotransporter KCC2

Current view on the functional regulation of the neuronal K+-Cl- cotransporter KCC2

In the mammalian central nervous system, the inhibitory strength of chloride (Cl-)-permeable GABAA and glycine receptors (GABAAR and GlyR) depends on the intracellular Cl- concentration ([Cl-]i). Lowering [Cl-]i enhances inhibition, whereas raising [Cl-]i facilitates neuronal activity. A neuron’s ba...

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Bibliographic Details
Main Authors: Igor eMedina, Perrine eFriedel, Claudio eRivera, Kristopher T Kahle, Nazim eKourdougli, Pavel eUvarov, Christophe ePellegrino
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-02-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Neurons
GABA
KCC2
ion homeostasis
intracellular chloride
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00027/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00027/full

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