Current view on the functional regulation of the neuronal K+-Cl- cotransporter KCC2
In the mammalian central nervous system, the inhibitory strength of chloride (Cl-)-permeable GABAA and glycine receptors (GABAAR and GlyR) depends on the intracellular Cl- concentration ([Cl-]i). Lowering [Cl-]i enhances inhibition, whereas raising [Cl-]i facilitates neuronal activity. A neuron’s ba...
Main Authors: | Igor eMedina, Perrine eFriedel, Claudio eRivera, Kristopher T Kahle, Nazim eKourdougli, Pavel eUvarov, Christophe ePellegrino |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2014-02-01
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Series: | Frontiers in Cellular Neuroscience |
Subjects: | |
Online Access: | http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00027/full |
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