Wu-Tou Decoction in Rheumatoid Arthritis: Integrating Network Pharmacology and In Vivo Pharmacological Evaluation

Wu-Tou Decoction in Rheumatoid Arthritis: Integrating Network Pharmacology and In Vivo Pharmacological Evaluation

Purpose: This study aimed to explore underlying action mechanism of Wu-Tou decoction (WTD) in rheumatoid arthritis (RA) through network pharmacology prediction and experimental verification.Methods: Chemical compounds and human target proteins of WTD as well as RA-related human genes were obtained f...

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Bibliographic Details
Main Authors: Qingqing Guo, Kang Zheng, Danping Fan, Yukun Zhao, Li Li, Yanqin Bian, Xuemei Qiu, Xue Liu, Ge Zhang, Chaoying Ma, Xiaojuan He, Aiping Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Pharmacology
Subjects:
Wu-Tou decoction
rheumatoid arthritis
mechanism of action
network pharmacology
CCR5 signaling pathway in macrophages
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00230/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00230/full

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