Identification, design and bio-evaluation of novel Hsp90 inhibitors by ligand-based virtual screening.

Identification, design and bio-evaluation of novel Hsp90 inhibitors by ligand-based virtual screening.

Heat shock protein 90 (Hsp90), whose inhibitors have shown promising activity in clinical trials, is an attractive anticancer target. In this work, we first explored the significant pharmacophore features needed for Hsp90 inhibitors by generating a 3D-QSAR pharmacophore model. It was then used to vi...

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Bibliographic Details
Main Authors: JianMin Jia, XiaoLi Xu, Fang Liu, XiaoKe Guo, MingYe Zhang, MengChen Lu, LiLi Xu, JinLian Wei, Jia Zhu, ShengLie Zhang, ShengMiao Zhang, HaoPeng Sun, QiDong You
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3615092?pdf=render

Internet

http://europepmc.org/articles/PMC3615092?pdf=render

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