Targeting SLP76:ITK interaction separates GVHD from GVL in allo-HSCT

Targeting SLP76:ITK interaction separates GVHD from GVL in allo-HSCT

Summary: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative therapy for hematological malignancies, due to graft-versus-leukemia (GVL) activity mediated by alloreactive donor T cells. However, graft-versus-host disease (GVHD) is also mediated by these cells. Here, we assess...

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Bibliographic Details
Main Authors: Mahinbanu Mammadli, Weishan Huang, Rebecca Harris, Hui Xiong, Samuel Weeks, Adriana May, Teresa Gentile, Jessica Henty-Ridilla, Adam T. Waickman, Avery August, Alaji Bah, Mobin Karimi
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:iScience
Subjects:
Molecular Biology
Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221002546

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http://www.sciencedirect.com/science/article/pii/S2589004221002546

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