Primary Immune Responses and Affinity Maturation Are Controlled by IgD

Primary Immune Responses and Affinity Maturation Are Controlled by IgD

Mature B cells co-express IgM and IgD B cell antigen receptors (BCR) on their surface. While IgM BCR expression is already essential at early stages of development, the role of the IgD-class BCR remains unclear as most B cell functions appeared unchanged in IgD-deficient mice. Here, we show that IgD...

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Bibliographic Details
Main Authors: Timm Amendt, Omar El Ayoubi, Alexandra T. Linder, Gabriele Allies, Marc Young, Corinna S. Setz, Hassan Jumaa
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Immunology
Subjects:
B cell selection
IgD
antigen-valency
autoimmunity
IgM
tolerance
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.709240/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.709240/full

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