Development of Quorum-Based Anti-Virulence Therapeutics Targeting Gram-Negative Bacterial Pathogens

Development of Quorum-Based Anti-Virulence Therapeutics Targeting Gram-Negative Bacterial Pathogens

Quorum sensing is a cell density-dependent signaling phenomenon used by bacteria for coordination of population-wide phenotypes, such as expression of virulence genes, antibiotic resistance and biofilm formation. Lately, disruption of bacterial communication has emerged as an anti-virulence strategy...

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Bibliographic Details
Main Authors: Wen Shan Yew, Song Buck Tay
Format: Article
Language:English
Published: MDPI AG 2013-08-01
Series:International Journal of Molecular Sciences
Subjects:
quorum sensing
anti-virulence
Gram-negative
quorum quenching
bacterial communication
N-acylhomoserine lactone
bacterial pathogens
disruption
inhibition
Online Access:http://www.mdpi.com/1422-0067/14/8/16570

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http://www.mdpi.com/1422-0067/14/8/16570

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