Recognition Patterns of the C1/C2 Epitopes Involved in Fc-Mediated Response in HIV-1 Natural Infection and the RV114 Vaccine Trial

Recognition Patterns of the C1/C2 Epitopes Involved in Fc-Mediated Response in HIV-1 Natural Infection and the RV114 Vaccine Trial

Antibody-dependent cellular cytotoxicity (ADCC) correlated with a reduced risk of infection from HIV-1 in the RV144 vaccine trial, the only HIV-1 vaccine trial to date to show any efficacy. Antibodies specific for CD4-induced envelope (Env) epitopes within constant region 1 and 2 (cluster A region)...

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Bibliographic Details
Main Authors: William D. Tolbert, Verna Van, Rebekah Sherburn, Marina Tuyishime, Fang Yan, Dung N. Nguyen, Sherry Stanfield-Oakley, David Easterhoff, Mattia Bonsignori, Barton F. Haynes, M. Anthony Moody, Krishanu Ray, Guido Ferrari, George K. Lewis, Marzena Pazgier
Format: Article
Language:English
Published: American Society for Microbiology 2020-06-01
Series:mBio
Subjects:
rv144
human immunodeficiency virus
structural biology
vaccines
Online Access:https://doi.org/10.1128/mBio.00208-20

Internet

https://doi.org/10.1128/mBio.00208-20

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