Tocilizumab decreases T cells but not macrophages in the synovium of patients with rheumatoid arthritis while it increases the levels of serum interleukin-6 and RANKL

Tocilizumab decreases T cells but not macrophages in the synovium of patients with rheumatoid arthritis while it increases the levels of serum interleukin-6 and RANKL

Objectives Our knowledge about the effect of tocilizumab (TCZ) on the synovium in rheumatoid arthritis (RA) is limited. The aim of this study was to investigate the effect of TCZ on citrullination and on inflammation in the synovial tissue and in the peripheral blood.Methods 15 patients with RA unde...

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Bibliographic Details
Main Authors: Katerina Chatzidionysiou, Bence Rethi, Vijay Joshua, Alexandra Circiumaru, Marianne Engstrom, Anca Catrina, Erik af Klint, Aase Hensvold
Format: Article
Language:English
Published: BMJ Publishing Group 2021-08-01
Series:RMD Open
Online Access:https://rmdopen.bmj.com/content/7/2/e001662.full

Internet

https://rmdopen.bmj.com/content/7/2/e001662.full

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