Ceramide Kinase Contributes to Proliferation but not to Prostaglandin E2 Formation in Renal Mesangial Cells and Fibroblasts

Ceramide Kinase Contributes to Proliferation but not to Prostaglandin E2 Formation in Renal Mesangial Cells and Fibroblasts

Background/Aims: Ceramide kinase (CerK) catalyzes the generation of the sphingolipid ceramide-1-phosphate (C1P) which regulates various cellular functions including cell growth and death, and inflammation. Here, we used a novel catalytic inhibitor of CerK, NVP-231, and CerK knockout cells to investi...

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Bibliographic Details
Main Authors: Oleksandr Pastukhov, Stephanie Schwalm, Isolde Römer, Uwe Zangemeister-Wittke, Josef Pfeilschifter, Andrea Huwiler
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2014-06-01
Series:Cellular Physiology and Biochemistry
Subjects:
Apoptosis
Prostaglandin E2
Mesangial cells
Fibroblasts
Proliferation
M phase arrest
Ceramide kinase
NVP-231
Online Access:http://www.karger.com/Article/FullText/362989

Internet

http://www.karger.com/Article/FullText/362989

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