Superoxide dismutase reduces monosodium glutamate-induced injury in an organotypic whole hemisphere brain slice model of excitotoxicity

Superoxide dismutase reduces monosodium glutamate-induced injury in an organotypic whole hemisphere brain slice model of excitotoxicity

Abstract Background Knowledge of glutamate excitotoxicity has increased substantially over the past few decades, with multiple proposed pathways involved in inflicting damage. We sought to develop a monosodium glutamate (MSG) exposed ex vivo organotypic whole hemisphere (OWH) brain slice model of ex...

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Bibliographic Details
Main Authors: Rick Liao, Thomas R. Wood, Elizabeth Nance
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Journal of Biological Engineering
Subjects:
Oxidative stress
Peroxynitrite
Mitochondria
Neuroinflammation
Hyperosmolar stress
8-hydroxy-2-deoxyguanosine
Online Access:https://doi.org/10.1186/s13036-020-0226-8

Internet

https://doi.org/10.1186/s13036-020-0226-8

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