Tregs facilitate obesity and insulin resistance via a Blimp-1/IL-10 axis

Tregs facilitate obesity and insulin resistance via a Blimp-1/IL-10 axis

Interleukin-10 (IL-10) is a critical cytokine used by immune cells to suppress inflammation. Paradoxically, immune cell–derived IL-10 can drive insulin resistance in obesity by suppressing adipocyte energy expenditure and thermogenesis. However, the source of IL-10 necessary for the suppression of a...

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Bibliographic Details
Main Authors: Lisa Y. Beppu, Raja Gopal Reddy Mooli, Xiaoyao Qu, Giovanni J. Marrero, Christopher A. Finley, Allen N. Fooks, Zachary P. Mullen, Adolfo B. Frias Jr., Ian Sipula, Bingxian Xie, Katherine E. Helfrich, Simon C. Watkins, Amanda C. Poholek, Sadeesh K. Ramakrishnan, Michael J. Jurczak, Louise M. D’Cruz
Format: Article
Language:English
Published: American Society for Clinical investigation 2021-02-01
Series:JCI Insight
Subjects:
Endocrinology
Immunology
Online Access:https://doi.org/10.1172/jci.insight.140644

Internet

https://doi.org/10.1172/jci.insight.140644

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