Metabolomic Profiling of the Effects of Melittin on Cisplatin Resistant and Cisplatin Sensitive Ovarian Cancer Cells Using Mass Spectrometry and Biolog Microarray Technology

Metabolomic Profiling of the Effects of Melittin on Cisplatin Resistant and Cisplatin Sensitive Ovarian Cancer Cells Using Mass Spectrometry and Biolog Microarray Technology

In the present study, liquid chromatography-mass spectrometry (LC-MS) was employed to characterise the metabolic profiles of two human ovarian cancer cell lines A2780 (cisplatin-sensitive) and A2780CR (cisplatin-resistant) in response to their exposure to melittin, a cytotoxic peptide from bee venom...

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Bibliographic Details
Main Authors: Sanad Alonezi, Jonans Tusiimire, Jennifer Wallace, Mark J. Dufton, John A. Parkinson, Louise C. Young, Carol J. Clements, Jin Kyu Park, Jong Woon Jeon, Valerie A. Ferro, David G. Watson
Format: Article
Language:English
Published: MDPI AG 2016-10-01
Series:Metabolites
Subjects:
metabolomics
Melittin
LC-MS
ovarian cancer
A2780 cells
cisplatin resistance
Online Access:http://www.mdpi.com/2218-1989/6/4/35

Internet

http://www.mdpi.com/2218-1989/6/4/35

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