Synthesis and Evaluation of New Pyrazoline Derivatives as Potential Anticancer Agents

Synthesis and Evaluation of New Pyrazoline Derivatives as Potential Anticancer Agents

New pyrazoline derivatives were synthesized and evaluated for their cytotoxic effects on AsPC-1 human pancreatic adenocarcinoma, U87 and U251 human glioblastoma cell lines. 1-[((5-(4-Methylphenyl)-1,3,4-oxadiazol-2-yl)thio)acetyl]-3-(2-thienyl)-5-(4-chlorophenyl)-2-pyrazoline (11) was found to be th...

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Bibliographic Details
Main Authors: Muhammed Karabacak, Mehlika Dilek Altıntop, Halil İbrahim Çiftçi, Ryoko Koga, Masami Otsuka, Mikako Fujita, Ahmet Özdemir
Format: Article
Language:English
Published: MDPI AG 2015-10-01
Series:Molecules
Subjects:
pyrazoline
oxadiazole
anticancer activity
apoptosis
DNA cleavage
Online Access:http://www.mdpi.com/1420-3049/20/10/19066

Internet

http://www.mdpi.com/1420-3049/20/10/19066

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