Cancer screening by systemic administration of a gene delivery vector encoding tumor-selective secretable biomarker expression.

Cancer screening by systemic administration of a gene delivery vector encoding tumor-selective secretable biomarker expression.

Cancer biomarkers facilitate screening and early detection but are known for only a few cancer types. We demonstrated the principle of inducing tumors to secrete a serum biomarker using a systemically administered gene delivery vector that targets tumors for selective expression of an engineered cas...

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Bibliographic Details
Main Authors: Andrew W Browne, Jennifer L Leddon, Mark A Currier, Jon P Williams, Jason S Frischer, Margaret H Collins, Chong H Ahn, Timothy P Cripe
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-05-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3092745?pdf=render

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http://europepmc.org/articles/PMC3092745?pdf=render

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