Cancer screening by systemic administration of a gene delivery vector encoding tumor-selective secretable biomarker expression.
Cancer biomarkers facilitate screening and early detection but are known for only a few cancer types. We demonstrated the principle of inducing tumors to secrete a serum biomarker using a systemically administered gene delivery vector that targets tumors for selective expression of an engineered cas...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2011-05-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3092745?pdf=render |