Highly specific detection of myostatin prodomain by an immunoradiometric sandwich assay in serum of healthy individuals and patients.

BACKGROUND: Myostatin is a muscle derived factor that functions as a negative regulator of skeletal muscle growth. Induction of myostatin expression was observed in rodent models of muscle wasting and in cachectic patients with cancer or pulmonary disease. Therefore, there is an increasing interest...

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Main Authors: Astrid Breitbart, Gesine M Scharf, David Duncker, Christian Widera, Jens Gottlieb, Arndt Vogel, Sebastian Schmidt, Gudrun Brandes, Hans-Gert Heuft, Ralf Lichtinghagen, Tibor Kempf, Kai C Wollert, Johann Bauersachs, Joerg Heineke
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3829884?pdf=render