Inhibiting BDNF/TrkB.T1 receptor improves resiniferatoxin-induced postherpetic neuralgia through decreasing ASIC3 signaling in dorsal root ganglia

Inhibiting BDNF/TrkB.T1 receptor improves resiniferatoxin-induced postherpetic neuralgia through decreasing ASIC3 signaling in dorsal root ganglia

Abstract Background Postherpetic neuralgia (PHN) is a devastating complication after varicella-zoster virus infection. Brain-derived neurotrophic factor (BDNF) has been shown to participate in the pathogenesis of PHN. A truncated isoform of the tropomyosin receptor kinase B (TrkB) receptor TrkB.T1,...

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Bibliographic Details
Main Authors: Xiang Wei, Lina Wang, Jie Hua, Xiao-hong Jin, Fuhai Ji, Ke Peng, Bin Zhou, Jianping Yang, Xiao-wen Meng
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Journal of Neuroinflammation
Subjects:
Postherpetic neuralgia
Resiniferatoxin
Brain-derived neurotrophic factor
Truncated tropomyosin receptor kinase B receptor
Acid-sensitive ion channel 3
Neuronal excitability
Online Access:https://doi.org/10.1186/s12974-021-02148-5

Internet

https://doi.org/10.1186/s12974-021-02148-5

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