Tissue plasminogen activator inhibits NMDA-receptor-mediated increases in calcium levels in cultured hippocampal neurons

NMDA receptors (NMDARs) play a critical role in neurotransmission, acting as essential mediators of many forms of synaptic plasticity, and also modulating aspects of development, synaptic transmission and cell death. NMDAR-induced responses are dependent on a range of factors including subunit comp...

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Bibliographic Details
Main Authors: Samuel D Robinson, Tet Woo eLee, David L Christie, Nigel Peter Birch
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00404/full