LNX1 Modulates Notch1 Signaling to Promote Expansion of the Glioma Stem Cell Population during Temozolomide Therapy in Glioblastoma

LNX1 Modulates Notch1 Signaling to Promote Expansion of the Glioma Stem Cell Population during Temozolomide Therapy in Glioblastoma

Glioblastoma (GBM) is the most common primary brain malignancy in adults, with a 100% recurrence rate and 21-month median survival. Our lab and others have shown that GBM contains a subpopulation of glioma stem cells (GSCs) that expand during chemotherapy and may contribute to therapeutic resistance...

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Bibliographic Details
Main Authors: Shivani Baisiwala, Robert R. Hall, Miranda R. Saathoff, Jack M. Shireman, Cheol Park, Shreya Budhiraja, Chirag Goel, Louisa Warnke, Clare Hardiman, Jennifer Y. Wang, Katy McCortney, Craig M. Horbinski, Atique U. Ahmed
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Cancers
Subjects:
glioblastoma
Notch1
therapeutic resistance
glioma stem cell
LNX1
Online Access:https://www.mdpi.com/2072-6694/12/12/3505

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https://www.mdpi.com/2072-6694/12/12/3505

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