Allosteric activation of SENP1 by SUMO1 β-grasp domain involves a dock-and-coalesce mechanism

Allosteric activation of SENP1 by SUMO1 β-grasp domain involves a dock-and-coalesce mechanism

Small ubiquitin-related modifiers (SUMOs) are conjugated to proteins to regulate a variety of cellular processes. SENPs are cysteine proteases with a catalytic center located within a channel between two subdomains that catalyzes SUMO C-terminal cleavage for processing of SUMO precursors and de-SUMO...

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Bibliographic Details
Main Authors: Jingjing Guo, Huan-Xiang Zhou
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-08-01
Series:eLife
Subjects:
allosteric activation
SUMOylation
protein dynamics
dock-and-coalesce
Online Access:https://elifesciences.org/articles/18249

Internet

https://elifesciences.org/articles/18249

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