Fast skeletal muscle troponin activation increases force of mouse fast skeletal muscle and ameliorates weakness due to nebulin-deficiency.

Fast skeletal muscle troponin activation increases force of mouse fast skeletal muscle and ameliorates weakness due to nebulin-deficiency.

The effect of the fast skeletal muscle troponin activator, CK-2066260, on calcium-induced force development was studied in skinned fast skeletal muscle fibers from wildtype (WT) and nebulin deficient (NEB KO) mice. Nebulin is a sarcomeric protein that when absent (NEB KO mouse) or present at low lev...

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Bibliographic Details
Main Authors: Eun-Jeong Lee, Josine M De Winter, Danielle Buck, Jeffrey R Jasper, Fady I Malik, Siegfried Labeit, Coen A Ottenheijm, Henk Granzier
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3577798?pdf=render

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http://europepmc.org/articles/PMC3577798?pdf=render

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