Identification of Quinazolinone Analogs Targeting CDK5 Kinase Activity and Glioblastoma Cell Proliferation

Identification of Quinazolinone Analogs Targeting CDK5 Kinase Activity and Glioblastoma Cell Proliferation

CDK5/p25 kinase plays a major role in neuronal functions, and is hyperactivated in several human cancers including glioblastoma and neurodegenerative pathologies such as Alzheimer's and Parkinson's. CDK5 therefore constitutes an attractive pharmacological target. Since the successful disco...

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Bibliographic Details
Main Authors: Marion Peyressatre, Dominique Patomo Arama, Arthur Laure, Juan A. González-Vera, Morgan Pellerano, Nicolas Masurier, Vincent Lisowski, May C. Morris
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Chemistry
Subjects:
CDK5
kinase
conformational biosensor
quinazoline
small molecule inhibitor
fluorescence-based screening
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2020.00691/full

Internet

https://www.frontiersin.org/article/10.3389/fchem.2020.00691/full

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