Active inhibitor-1 maintains protein hyper-phosphorylation in aging hearts and halts remodeling in failing hearts.

Active inhibitor-1 maintains protein hyper-phosphorylation in aging hearts and halts remodeling in failing hearts.

Impaired sarcoplasmic reticulum calcium cycling and depressed contractility are key characteristics in heart failure. Defects in sarcoplasmic reticulum function are characterized by decreased SERCA2a Ca-transport that is partially attributable to dephosphorylation of its regulator phospholamban by i...

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Bibliographic Details
Main Authors: Tracy J Pritchard, Yoshiaki Kawase, Kobra Haghighi, Ahmad Anjak, Wenfeng Cai, Min Jiang, Persoulla Nicolaou, George Pylar, Ioannis Karakikes, Kleopatra Rapti, Jack Rubinstein, Roger J Hajjar, Evangelia G Kranias
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3846572?pdf=render

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http://europepmc.org/articles/PMC3846572?pdf=render

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