Specific activation of GluN1-N2B NMDA receptors underlies facilitation of cortical spreading depression in a genetic mouse model of migraine with reduced astrocytic glutamate clearance

Specific activation of GluN1-N2B NMDA receptors underlies facilitation of cortical spreading depression in a genetic mouse model of migraine with reduced astrocytic glutamate clearance

Migraine is a common but poorly understood sensory circuit disorder. Mouse models of familial hemiplegic migraine (FHM, a rare monogenic form of migraine with aura) show increased susceptibility to cortical spreading depression (CSD, the phenomenon that underlies migraine aura and can activate migra...

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Bibliographic Details
Main Authors: Giovanna Crivellaro, Angelita Tottene, Marina Vitale, Marcello Melone, Giorgio Casari, Fiorenzo Conti, Mirko Santello, Daniela Pietrobon
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Neurobiology of Disease
Subjects:
Migraine
Spreading depolarization
Spreading depression
α2 Na+
K+ ATPase
Astrocyte
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996121001686

Internet

http://www.sciencedirect.com/science/article/pii/S0969996121001686

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