Specific activation of GluN1-N2B NMDA receptors underlies facilitation of cortical spreading depression in a genetic mouse model of migraine with reduced astrocytic glutamate clearance
Migraine is a common but poorly understood sensory circuit disorder. Mouse models of familial hemiplegic migraine (FHM, a rare monogenic form of migraine with aura) show increased susceptibility to cortical spreading depression (CSD, the phenomenon that underlies migraine aura and can activate migra...
Main Authors: | Giovanna Crivellaro, Angelita Tottene, Marina Vitale, Marcello Melone, Giorgio Casari, Fiorenzo Conti, Mirko Santello, Daniela Pietrobon |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2021-08-01
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Series: | Neurobiology of Disease |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996121001686 |
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