Dramatic neurological and biological effects by botulinum neurotoxin type A on SH-SY5Y neuroblastoma cells, beyond the blockade of neurotransmitter release

Dramatic neurological and biological effects by botulinum neurotoxin type A on SH-SY5Y neuroblastoma cells, beyond the blockade of neurotransmitter release

Abstract Background Gene expression profile analysis on mammalian cell lines and animal models after exposure to botulinum neurotoxin (BoNT) has been investigated in several studies in recent years. Microarray analysis provides a powerful tool for identifying critical signaling pathways involved in...

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Bibliographic Details
Main Authors: Lei Wang, Carol S. Ringelberg, Bal R. Singh
Format: Article
Language:English
Published: BMC 2020-09-01
Series:BMC Pharmacology and Toxicology
Subjects:
Gene expression profile
Clostridium botulinum
Botulinum neurotoxin type A
Host response
Microarray analysis
Neuroblastoma SH-SY5Y cells
Online Access:http://link.springer.com/article/10.1186/s40360-020-00443-0

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http://link.springer.com/article/10.1186/s40360-020-00443-0

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