Partial Reversal of Tissue Calcification and Extension of Life Span following Ammonium Nitrate Treatment of Klotho-Deficient Mice
Background/Aims: Klotho is required for the inhibitory effect of FGF23 on 1,25(OH)2D3 formation and Klotho-hypomorphic mice (kl/kl) suffer from severe tissue calcification due to excessive 1,25(OH)2D3 formation with subsequent increase of Ca2+ and phosphate concentrations and stimulation of osteogen...
Main Authors: | , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Karger Publishers
2016-02-01
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Series: | Kidney & Blood Pressure Research |
Subjects: | |
Online Access: | http://www.karger.com/Article/FullText/443411 |