Partial Reversal of Tissue Calcification and Extension of Life Span following Ammonium Nitrate Treatment of Klotho-Deficient Mice

Partial Reversal of Tissue Calcification and Extension of Life Span following Ammonium Nitrate Treatment of Klotho-Deficient Mice

Background/Aims: Klotho is required for the inhibitory effect of FGF23 on 1,25(OH)2D3 formation and Klotho-hypomorphic mice (kl/kl) suffer from severe tissue calcification due to excessive 1,25(OH)2D3 formation with subsequent increase of Ca2+ and phosphate concentrations and stimulation of osteogen...

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Bibliographic Details
Main Authors: Christina B. Leibrock, Martina Feger, Jakob Voelkl, Ursula Kohlhofer, Leticia Quintanilla-Martinez, Makoto Kuro-o, Florian Lang
Format: Article
Language:English
Published: Karger Publishers 2016-02-01
Series:Kidney & Blood Pressure Research
Subjects:
Calcification
Aging
Life span
Acidosis
Chronic kidney disease
Klotho
1,25(OH)2D3
Phosphate
Calcium
Online Access:http://www.karger.com/Article/FullText/443411

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http://www.karger.com/Article/FullText/443411

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