A Hybrid Peptide DEFB-TP5 Expressed in Methylotrophic Yeast Neutralizes LPS With Potent Anti-inflammatory Activities

A Hybrid Peptide DEFB-TP5 Expressed in Methylotrophic Yeast Neutralizes LPS With Potent Anti-inflammatory Activities

DEFB-TP5 is a novel auspicious health-beneficial peptide derivative from two naturally occurring peptides, β-Defensin (DEFB) and thymopentin (TP5), and shows strong anti-inflammatory activity and binds to LPS without cytotoxicity and hemolytic effect. Furthermore, the application of DEFB-TP5 peptide...

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Bibliographic Details
Main Authors: Baseer Ahmad, Zhongxuan Li, Quratulain Hanif, Qingyong Hu, Xubiao Wei, Lulu Zhang, Shahzad Akbar Khan, Maierhaba Aihemaiti, Huma Gulzar, Muhammad Shahid, Dayong Si, Rijun Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Pharmacology
Subjects:
expression
hybrid peptide
β-defensins
endotoxin
anti-inflammatory
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00461/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00461/full

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